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Will Flagyl alone treat diverticulitis? Fluoroquinolones are widely used in the treatment of diverticulitis, because of their excellent activity against aerobic Gram-negative bacteria. Metronidazole (Flagyl) is highly active against anaerobic bacteria. Dosage: Ciprofloxacin (Cipro) 500 mg twice daily plus metronidazole 500 mg 3-4 times per day for 7-10 days.